The 1968 film 2001: A Space Odyssey suggested that we would have extensive space flight in 2001. That turned out not to be the case. What we did get was the September 11 attacks on the USA and the military conflicts which followed. Nevertheless, NASA commemorated the film with the 2001 Mars Odyssey orbiter.
Films of 2000 included the superb The Lord of the Rings: The Fellowship of the Ring, several good animated films (including Monsters, Inc., Shrek, and Hayao Miyazaki’s Spirited Away), the wonderful French film Amélie, some war movies (Enemy at the Gates was good, but Black Hawk Down distorted the book too much for my taste), the first Harry Potter movie, and an award-winning biographical film about the mathematician John Nash.
Saul Kripke (belatedly) received the Rolf Schock Prize in Logic and Philosophy for his work on Kripke semantics, while Ole-Johan Dahl and Kristen Nygaard (also belatedly) received the Turing Award for their work on object-oriented programming languages (both these pioneers of computing died the following year).
The year 2001 also saw the completion of the Cathedral of Saint Gregory the Illuminator in Armenia, which I have sadly never visited.